Welcome
Our Expertise
Ambesman is a data and research-driven consulting firm operating at the convergence of medicine, emerging AI technologies, and public policy. We deliver strategic insight across healthcare AI, medical-legal consulting, interventional pain practice strategy, longevity science, and regenerative health.
With a firm commitment to Centers for Medicare & Medicaid Services (CMS) vision for a secure, patient-centered, and interoperable health ecosystem, we help innovators, clinics, and institutions integrate responsible AI, reduce administrative burden, enhance data transparency, and align with evolving regulatory standards. From evaluating AI readiness in clinical settings to advising on value-based models, our multidisciplinary team supports the safe and equitable deployment of technologies that advance outcomes for all patients.
Who are we
Get to Know Us
Ambesman is a multidisciplinary consulting firm led by a world-class team with expertise in AI research, healthcare operations, and regulatory strategy—committed to shaping the future of equitable, patient-centered care.
Our AI researchers have published in the top 1% of international AI conferences, including NeurIPS and ICLR, and have co-authored influential research alongside leading institutions such as MIT.
As an independent benchmarking body, Ambesman applies this research rigor to evaluate healthcare AI technologies against the evolving standards set by the CMS. Our work supports the safe, effective, and ethical deployment of digital health tools—advancing interoperability, reducing administrative burden, and improving outcomes across CMS as well as privately insured populations.
Mission
Delivering data-driven, CMS-aligned strategies accelerating healthcare transformation.
Our mission is to champion scalable, secure, and people-centered healthcare AI solutions aligned with the Centers for Medicare & Medicaid Services' current objectives, advancing interoperability across providers, payers, and platforms.
Ambesman exists to help organizations and individuals navigate complexity with confidence. Whether consulting on AI integration, regenerative medicine, or personalized longevity, we are committed to delivering high-impact insight rooted in real-world evidence, digital accessibility, and forward-thinking design.
We champion innovation that is not just cutting-edge—but trusted, inclusive, and aligned with the evolving health technology landscape.
Vision
Redefining human health through ethical, AI-powered innovation
Our vision is a future where healthcare AI empowers Medicare and Medicaid beneficiaries with seamless, secure access to interoperable data—anchored by CMS’s digital health objectives. We enable patient-centered innovation through scalable AI solutions that integrate FHIR-based APIs, support digital identity frameworks, reduce administrative burden, and advance equitable value-based care.
As an independent, multidisciplinary entity, Ambesman advances this vision by rigorously benchmarking healthcare AI tools to ensure they are safe, effective, and aligned with CMS’s evolving standards—building the trust needed for ethical and impactful innovation at scale.
Dr. John V. Prunskis, M.D., F.I.P.P.
Physician • Diplomat • Educator • Entrepreneur
Dr. John V. Prunskis, MD, FIPP, is a double-board-certified interventional pain physician internationally recognized for his leadership in pain management, regenerative medicine, and healthcare innovation. He is the founder and Chief Medical Officer of the Illinois Pain & Spine Institute, established in 1992, and currently serves as Director and Chair of the Medical Executive Committee at DxTx Pain and Spine, which he co-founded in 2020. Under his leadership, DxTx has expanded to more than 60 clinics across 10 states and delivered over one million patient visits.
A 25-year Castle Connolly “Top Doctor” honoree as voted by his peers, Dr. Prunskis has dedicated his career to advancing evidence-based, minimally invasive treatments for chronic pain. Beyond clinical practice, he has played a pivotal role in shaping national policy, serving as a Presidential White House appointee to the U.S. Department of Health and Human Services Pain Management Best Practices Task Force and co-authoring its landmark 2019 Final Report.
He also served three consecutive four-year terms in the Lithuanian Parliament/World Lithuanian Community Commission representing 900,000 Lithuanian Americans. For his philanthropic and professional contributions, he was bestowed the Knight of the Order of Merit by the President of Lithuania.
He is Vice Chair of the American Society of Pain and Neuroscience’s Artificial Intelligence (AI) Division, serves on the Advisory Board of Hippocratic AI, and is the founder of The Regenerative Stem Cell Institute. With over four decades of expertise, Dr. Prunskis bridges clinical excellence, innovation, and thoughtful public policy to expand access to ethical, effective, and technology-driven healthcare.